Cutting Edge: Priming of CD8 T Cell Immunity to Herpes Simplex Virus Type 1 Requires Cognate TLR3 Expression In Vivo
- Author(s)
- Davey, GM; Wojtasiak, M; Proietto, AI; Carbone, FR; Heath, WR; Bedoui, S;
- Details
- Publication Year 2010-03-01,Volume 184,Issue #5,Page 2243-2246
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Despite its potential for involvement in viral immunity, little evidence links TLR3 to adaptive antiviral responses. Here we show that TLR3 is required for the generation of CD8 T cell immunity to HSV-1. The magnitude of the gB-specific CD8 T cell response after flank infection by HSV-1 was significantly reduced in mice lacking TIR domain-containing adaptor-inducing IFN-beta or TLR3, but not MyD88. Impaired CTL induction was evident in chimeric mice lacking TLR3 in bone marrow (BM)-derived cells. Among the dendritic cell subsets, TLR3 was expressed by CD8 alpha(+) dendritic cells, known to be involved in priming HSV-1-specific CD8 T cells. Use of mixed BM chimeras revealed that TLR3 and the MHC class I-restriction element must be expressed by the same BM-derived cell for effective priming. These data imply that a cognate linkage between TLR3 and MHC class I is required for efficient CTL priming to HSV-1. The Journal of Immunology, 2010, 184: 2243-2246.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Keywords
- TOLL-LIKE RECEPTOR-3; CD8-ALPHA(+) DENDRITIC CELLS; DOUBLE-STRANDED-RNA; RECOGNITION; INFECTIONS; DEFICIENCY; ACTIVATION; RESPONSES; SKIN
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Creation Date: 2010-03-01 12:00:00