Human Leukocyte Antigen-DR15, Low Infant Sibling Exposure and Multiple Sclerosis: Gene-Environment Interaction

Author(s): Van der Mei, IAF; Ponsonby, AL; Taylor, BV; Stankovich, J; Dickinson, JL; Foote, S; Kemp, A; Dwyer, T;
Details: Publication Year 2010-02,Volume 67,Issue #2,Page 261-265
Journal Title: ANNALS OF NEUROLOGY
Publication Type: Journal Article
Abstract: The risk for development of multiple sclerosis has been associated with human leukocyte antigen-DRB1*1501-DQB1*0602 (HLA-DR15) genotype, low infant sibling exposure, and high Epstein-Barr nuclear antigen IgG levels. In a population-based case-control study (Tasmania, Australia), we found that the combined effect of HLA-DR15 positivity and low infant sibling exposure on multiple sclerosis (odds ratio, 7.88; 95% confidence interval, 3.43-18.11) was 3.9-fold greater than expected (test for interaction, p = 0.019) This interaction was observed irrespective of Epstein-Barr nuclear antigen IgG levels. This suggests that immune mechanisms involving HLA class II molecules are susceptible to modulation in early life. Ann Neurol 2009;66:261-265 ANN NEUROL 2010;67:259-263
Publisher: WILEY-LISS
Keywords: EPSTEIN-BARR-VIRUS; SUN EXPOSURE; EARLY-LIFE; RISK; COHORT; ONSET
Publisher's Version: https://doi.org/10.1002/ana.21849
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2010-02-01 12:00:00