Intrinsically Disordered Proteins in Bcl-2 Regulated Apoptosis
Details
Publication Year 2010-04, Volume 11, Issue #4, Page 1808-1824
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Publication Type
Journal Article
Abstract
Intrinsic cell death is mediated by interaction between pro-apoptotic and prosurvival proteins of the B-cell lymphoma-2 (Bcl-2) family. Members of this family are either intrinsically disordered or contain intrinsically disordered regions/domains that are critical to their function. Alternate splicing and post-translational modifications can determine the extent of these disordered regions and are critical for regulating Bcl-2 proteins. Conformational plasticity and structural transitions characterize the interactions within the Bcl-2 family, with conserved sequence motifs on both binding partners required for their molecular recognition.
Publisher
MDPI AG
Keywords
CELL-DEATH MACHINERY; DYNEIN LIGHT-CHAIN; BH3-ONLY PROTEINS; FAMILY-MEMBERS; MITOCHONDRIAL-MEMBRANE; UNSTRUCTURED PROTEINS; SIGNALING PATHWAY; CRYSTAL-STRUCTURE; INDUCE APOPTOSIS; STRUCTURAL BASIS
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2010-04-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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