Critical roles for c-Myb in lymphoid priming and early B-cell development
- Author(s)
- Greig, KT; de Graaf, CA; Murphy, JM; Carpinelli, MR; Pang, SHM; Frampton, J; Kile, BT; Hilton, DJ; Nutt, SL;
- Details
- Publication Year 2010-04-08,Volume 115,Issue #14,Page 2796-2805
- Journal Title
- BLOOD
- Publication Type
- Journal Article
- Abstract
- c-Myb is a transcription factor with functions in many hematopoietic lineages. c-Myb-deficient mice display reduced numbers of B cells; however, it is unknown what role c-Myb plays in B lymphopoiesis because no critical target genes have been identified in the B-cell lineage. We demonstrate that conditional deletion of c-Myb in B-cell progenitors completely abolishes B-cell development. c-Myb is required for lymphoid progenitors to respond to the cytokines interleukin-7 and thymic stromal lymphopoietin; in the absence of sufficient c-Myb activity, mice display a B lymphopenia that closely resembles that observed in interleukin-7 receptor alpha-deficient animals. Analysis of the multipotent progenitor compartment indicates that c-Myb is also required for up-regulation of multiple lymphoidassociated genes, including Il7r, and for the subsequent development of the common lymphoid progenitor population. These data show that c-Myb plays a critical role in the regulatory pathways governing lymphoid specification and early B-cell differentiation. (Blood. 2010; 115(14): 2796-2805)
- Publisher
- AMER SOC HEMATOLOGY
- Keywords
- HEMATOPOIETIC PROGENITOR CELLS; BONE-MARROW; STEM-CELLS; MULTIPOTENT PROGENITORS; INTERLEUKIN-7 RECEPTOR; LINEAGE COMMITMENT; IL-7 RECEPTOR; RAG1 LOCUS; IN-VITRO; GENE
- Publisher's Version
- https://doi.org/10.1182/blood-2009-08-239210
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2010-04-08 12:00:00