Mutation discovery in mice by whole exome sequencing
Details
Publication Year 2011, Volume 12, Issue #9, Page -
Journal Title
GENOME BIOLOGY
Publication Type
Journal Article
Abstract
We report the development and optimization of reagents for in-solution, hybridization-based capture of the mouse exome. By validating this approach in a multiple inbred strains and in novel mutant strains, we show that whole exome sequencing is a robust approach for discovery of putative mutations, irrespective of strain background. We found strong candidate mutations for the majority of mutant exomes sequenced, including new models of orofacial clefting, urogenital dysmorphology, kyphosis and autoimmune hepatitis.
Publisher
BIOMED CENTRAL LTD
Keywords
BALANCER CHROMOSOME; HEARING-LOSS; MOUSE
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2011-01-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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