Blimp1: Driving Terminal Differentiation to a T
- Author(s)
- Xin, A; Nutt, SL; Belz, GT; Kallies, A;
- Journal Title
- CROSSROADS BETWEEN INNATE AND ADAPTIVE IMMUNITY III
- Publication Type
- S
- Abstract
- B lymphocyte maturation-induced protein-1 (Blimp1) is a transcriptional repressor expressed in diverse cell types. In the adaptive immune system, Blimp1 is expressed in lymphocytes that have undergone effector differentiation. Blimp1 is a master regulator of plasma cell differentiation and plays important roles in controlling T cell homeostasis and effector differentiation. Blimp1 can be induced by a variety of cytokines including IL-2, IL-4, IL-12, and IL-21 in addition to TCR and co-stimulatory signals. Blimp I-deficient mice develop spontaneous inflammatory disease mediated by infiltration of activated T cells into tissues. During immune responses Blimp I is required for the differentiation of plasma cells as well as short-lived CD8(+) cytotoxic T cells. Mounting evidence suggests that Blimp1 plays a common role in the terminal differentiation of multiple cell subsets.
- Publisher
- SPRINGER-VERLAG BERLIN
- Keywords
- PLASMA-CELL DIFFERENTIATION; INTERFERON-REGULATORY FACTOR-4; MEMORY B-CELLS; TRANSCRIPTIONAL REPRESSOR BLIMP-1; INDUCED MATURATION PROTEIN-1; GENE-EXPRESSION; OSTEOCLAST DIFFERENTIATION; SELECTIVE EXPRESSION; LYMPHOCYTE FUNCTION; LINEAGE COMMITMENT
- Publisher's Version
- https://doi.org/10.1007/978-1-4419-5632-3_8
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2011-01-01 12:00:00