Selective Depletion of Cross-Presenting Dendritic Cells Enhances Islet Allograft Survival

Author(s): Sutherland, RM; Zhan, YF; Carrington, EM; Londrigan, SL; Lew, AM;
Details: Publication Year 2011,Volume 20,Issue #3,Page 467-474
Journal Title: CELL TRANSPLANTATION
Publication Type: Journal Article
Abstract: MHC class I presentation of peptides derived from exogenous antigens (not synthesized within the antigen-presenting cell) is called cross-presentation and is mediated by selective subsets of dendritic cells (DC). A proportion of both donor and host DC may cross-present. Although there has been many studies that have investigated the role of donor versus host DC (i.e., direct vs. indirect pathway), what role cross-presenting DC play in allograft rejection has not been determined. We recently identified an agent, cytochrome c (cytc), that selectively depletes cross-presenting DC in vivo. By administering cytc we were able to study the impact of cross-presenting DC on rejection of islets grafted into fully mismatched mice. We found that cytc protected about half of the islet allografts from rejection. Our results indicate that cross-presenting DC can make potent contributions to the immune response to islet allografts, and contend that agents such as cytc that selectively target DC heralds a novel method of immunosuppression.
Publisher: COGNIZANT COMMUNICATION CORP
Publisher's Version: https://doi.org/10.3727/096368910X528094
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2011-01-01 12:00:00