Cell fate takes a slug in BRCA1-associated breast cancer

Author(s): Lindeman, GJ; Visvader, JE;
Details: Publication Year 2011,Volume 13,Issue #2,Page -
Journal Title: BREAST CANCER RESEARCH
Publication Type: Journal Article
Abstract: Understanding why BRCA1 mutation carriers have a predilection for developing clinically aggressive basal-like breast tumors could inform the development of targeted treatment or prevention strategies. Analysis of both mouse and human mammary epithelial cells has identified a role for BRCA1 in orchestrating differentiation. The ability to isolate discrete epithelial subpopulations from mammary tissue has recently directed attention to luminal progenitor cells - the descendants of mammary stem cells - as the likely 'cells-of-origin' in BRCA1-associated breast cancer. A new publication has confirmed the importance of aberrant luminal cells as key culprits and provided insights on how BRCA1 haploinsufficiency biases luminal cells toward a basal-like fate through aberrant expression of the transcription factor SLUG.
Publisher: BIOMED CENTRAL LTD
Keywords: MAMMARY EPITHELIAL-CELLS; BRCA1 MUTATION CARRIERS; STEM-CELLS; MESENCHYMAL TRANSITION; DIFFERENTIATION; PHENOTYPE; PROLIFERATION; PROGENITORS
Research Division(s): Stem Cells And Cancer
Publisher's Version: https://doi.org/10.1186/bcr2840
Open Access at Publisher's Site: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219185/

Creation Date: 2011-01-01 12:00:00