A Research Agenda for Malaria Eradication: Basic Science and Enabling Technologies
- Author(s)
- Baum, J; Billker, O; Bousema, T; Dinglasan, R; McGovern, V; Mota, MM; Mueller, I; Sinden, R;
- Details
- Publication Year 2011-01,Volume 8,Issue #1,Page -
- Journal Title
- PLOS MEDICINE
- Publication Type
- Journal Article
- Abstract
- Today's malaria control efforts are limited by our incomplete understanding of the biology of Plasmodium and of the complex relationships between human populations and the multiple species of mosquito and parasite. Research priorities include the development of in vitro culture systems for the complete life cycle of P. falciparum and P. vivax and the development of an appropriate liver culture system to study hepatic stages. In addition, genetic technologies for the manipulation of Plasmodium need to be improved, the entire parasite metabolome needs to be characterized to identify new druggable targets, and improved information systems for monitoring the changes in epidemiology, pathology, and host-parasite-vector interactions as a result of intensified control need to be established to bridge the gap between bench, preclinical, clinical, and population-based sciences.
- Publisher
- PUBLIC LIBRARY SCIENCE
- Keywords
- RED-BLOOD-CELLS; SACCHAROMYCES-CEREVISIAE GENOME; PARASITE PLASMODIUM-FALCIPARUM; ARTEMISININ RESISTANCE; DRUG DEVELOPMENT; MOSQUITO STAGES; AOTUS-MONKEYS; LIVER STAGE; STEM-CELLS; VIVAX
- Research Division(s)
- Infection And Immunity
- Publisher's Version
- https://doi.org/10.1371/journal.pmed.1000399
- Open Access at Publisher's Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026698/- Terms of Use/Rights Notice
- Copyright The malERA Consultative Group on Basic Science and Enabling Technologies. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Creation Date: 2011-01-01 12:00:00