Embryonic origin of the adult hematopoietic system: advances and questions
Details
Publication Year 2011-03-15, Volume 138, Issue #6, Page 1017-1031
Journal Title
DEVELOPMENT
Publication Type
Journal Article
Abstract
Definitive hematopoietic stem cells (HSCs) lie at the foundation of the adult hematopoietic system and provide an organism throughout its life with all blood cell types. Several tissues demonstrate hematopoietic activity at early stages of embryonic development, but which tissue is the primary source of these important cells and what are the early embryonic ancestors of definitive HSCs? Here, we review recent advances in the field of HSC research that have shed light on such questions, while setting them into a historical context, and discuss key issues currently circulating in this field.
Publisher
COMPANY OF BIOLOGISTS LTD
Keywords
STEM-CELL EMERGENCE; MURINE YOLK-SAC; GONAD-MESONEPHROS REGION; MOUSE EMBRYO; ENDOTHELIAL-CELLS; DEFINITIVE HEMATOPOIESIS; PROGENITOR CELLS; FETAL LIVER; DORSAL AORTA; IN-VIVO
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2011-03-15 12:00:00
Last Modified: 0001-01-01 12:00:00
An error has occurred. This application may no longer respond until reloaded. Reload 🗙