3-Alkylthio-1,2,4-triazine dimers with potent antimalarial activity
Details
Publication Year 2010-10-15, Volume 20, Issue #20, Page 6024-6029
Journal Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Publication Type
Journal Article
Abstract
We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells. They are equipotent against chloroquine-resistant strains of P. falciparum. (c) 2010 Elsevier Ltd. All rights reserved.
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
1,2,4-TRIAZINES
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2010-10-15 12:00:00
Last Modified: 0001-01-01 12:00:00
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