Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow
- Author(s)
- Winter, O; Moser, K; Mohr, E; Zotos, D; Kaminski, H; Szyska, M; Roth, K; Wong, DM; Dame, C; Tarlinton, DM; Schulze, H; MacLennan, ICM; Manz, RA;
- Details
- Publication Year 2010-09-16,Volume 116,Issue #11,Page 1867-1875
- Journal Title
- BLOOD
- Publication Type
- Journal Article
- Abstract
- Long-lived plasma cells in the bone marrow produce memory antibodies that provide immune protection persisting for decades after infection or vaccination but can also contribute to autoimmune and allergic diseases. However, the composition of the microenvironmental niches that are important for the generation and maintenance of these cells is only poorly understood. Here, we demonstrate that, within the bone marrow, plasma cells interact with the platelet precursors (megakaryocytes), which produce the prominent plasma cell survival factors APRIL (a proliferation-inducing ligand) and IL-6 (interleukin-6). Accordingly, reduced numbers of immature and mature plasma cells are found in the bone marrow of mice deficient for the thrombopoietin receptor (c-mpl) that show impaired megakaryopoiesis. After immunization, accumulation of antigen-specific plasma cells in the bone marrow is disturbed in these mice. Vice versa, injection of thrombopoietin allows the accumulation and persistence of a larger number of plasma cells generated in the course of a specific immune response in wild-type mice. These results demonstrate that megakaryocytes constitute an important component of the niche for long-lived plasma cells in the bone marrow. (Blood. 2010; 116(11): 1867-1875)
- Publisher
- AMER SOC HEMATOLOGY
- Keywords
- HEMATOPOIETIC STEM-CELLS; HUMORAL IMMUNITY; VASCULAR NICHE; DENDRITIC CELLS; STROMAL CELLS; MICE LACKING; B-CELLS; C-MPL; MAINTENANCE; SURVIVAL
- Publisher's Version
- https://doi.org/10.1182/blood-2009-12-259457
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2010-09-16 12:00:00