Observations on screening-based research and some concerning trends in the literature
- Author(s)
- Baell, JB;
- Details
- Publication Year 2010-10,Volume 2,Issue #10,Page 1529-1546
- Journal Title
- FUTURE MEDICINAL CHEMISTRY
- Publication Type
- Journal Article
- Abstract
- Academic drug discovery is being accompanied by a plethora of publications that report screening hits as good starting points for drug discovery or as useful tool compounds, whereas in many cases this is not so. These compounds may be protein-reactive but can also interfere in bioassays via a number of other means, and it can be very hard to prove early on that they represent false starts. This, for instance, makes it difficult for journals in their assessment of manuscripts submitted for publication. Wider awareness and recognition of these problematic compounds will help the academic drug-discovery community focus on and publish genuinely optimizable screening hits. This will be of general benefit.
- Publisher
- FUTURE SCI LTD
- Keywords
- SMALL-MOLECULE INHIBITORS; FALSE POSITIVES; IDENTIFICATION; RECEPTOR; BINDING; ALPHA; ASSAY; COMPLEXES; LIBRARIES; PROTEINS
- Publisher's Version
- https://doi.org/10.4155/FMC.10.237
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2010-10-01 12:00:00