CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche
Details
Publication Year 2009-03-10, Volume 106, Issue #10, Page 3895-3900
Journal Title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publication Type
Journal Article
Abstract
Plasma cells represent the end stage of B-cell development and play a key role in providing an efficient antibody response, but they are also involved in numerous pathologies. Here we show that CD93, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre) plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. T-independent and T-dependent stimuli led to re-expression of CD93 via 2 pathways, either before or after CD138 or Blimp-1 expression. Strikingly, while humoral immune responses initially proceeded normally, CD93-deficient mice were unable to maintain antibody secretion and bone-marrow plasmacell numbers, demonstrating that CD93 is important for the maintenance of plasma cells in bone marrow niches.
Publisher
NATL ACAD SCIENCES
Keywords
B-CELLS; C1Q-MEDIATED ENHANCEMENT; VIRAL-INFECTION; BLIMP-1; EXPRESSION; PROTEIN; DIFFERENTIATION; PHAGOCYTOSIS; ANTIGEN; AUTOIMMUNITY
Rights Notice
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Creation Date: 2009-03-10 12:00:00
Last Modified: 0001-01-01 12:00:00
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