CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche
- Chevrier, S; Genton, C; Kallies, A; Karnowski, A; Otten, LA; Malissen, B; Malissen, M; Botto, M; Corcoran, LM; Nutt, SL; Acha-Orbea, H;
Publication Year 2009-03-10, Volume 106, Issue #10, Page 3895-3900
- Journal Title
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Publication Type
- Journal Article
- Plasma cells represent the end stage of B-cell development and play a key role in providing an efficient antibody response, but they are also involved in numerous pathologies. Here we show that CD93, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre) plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. T-independent and T-dependent stimuli led to re-expression of CD93 via 2 pathways, either before or after CD138 or Blimp-1 expression. Strikingly, while humoral immune responses initially proceeded normally, CD93-deficient mice were unable to maintain antibody secretion and bone-marrow plasmacell numbers, demonstrating that CD93 is important for the maintenance of plasma cells in bone marrow niches.
- NATL ACAD SCIENCES
- B-CELLS; C1Q-MEDIATED ENHANCEMENT; VIRAL-INFECTION; BLIMP-1; EXPRESSION; PROTEIN; DIFFERENTIATION; PHAGOCYTOSIS; ANTIGEN; AUTOIMMUNITY
- Publisher's Version
- Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2009-03-10 12:00:00Last Modified: 0001-01-01 12:00:00