The role of the ETS factor erg in zebrafish vasculogenesis
Details
Publication Year 2009-03, Volume 126, Issue #3-4, Page 220-229
Journal Title
MECHANISMS OF DEVELOPMENT
Publication Type
Journal Article
Abstract
Erg, a member of the ETS family of transcription factors, has been implicated by previous studies in endothelial and haematopoietic development. Deregulation of the human ERG locus is associated with acute myeloid leukaemia, prostate cancer and Ewing's sarcoma. To better understand the role of Erg during early development, we utilised the zebrafish as a model amenable to descriptive and functional studies in vivo. Zebrafish have a single erg gene that is expressed in mesoderm and its vascular derivatives during angioblast migration, vasculogenesis and early angiogenesis. Mutant and morphant expression analyses placed erg in a genetic pathway downstream of cloche, tal1/scl and etsrp during early angioblast migration. Furthermore, a combination of gain-of-function and loss-of-function studies suggested a redundant yet specific role for erg in both angioblast specification/proliferation and early angiogenesis, and a synergistic interaction with the critical ETS factor etsrp. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Publisher
ELSEVIER SCIENCE BV
Keywords
TRANSCRIPTION FACTOR ERG; ENDOTHELIAL-CELL DIFFERENTIATION; VASCULAR DEVELOPMENT; REGULATES ANGIOGENESIS; MYELOID-LEUKEMIA; BINDING PROTEIN; DNA-BINDING; GENE; FAMILY; EXPRESSION
Rights Notice
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Creation Date: 2009-03-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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