Cross-presentation of viral and self antigens by skin-derived CD103(+) dendritic cells
- Bedoui, S; Whitney, PG; Waithman, J; Eidsmo, L; Wakim, L; Caminschi, I; Allan, RS; Wojtasiak, M; Shortman, K; Carbone, FR; Brooks, AG; Heath, WR;
Publication Year 2009-05, Volume 10, Issue #5, Page 488-495
- Journal Title
- NATURE IMMUNOLOGY
- Publication Type
- Journal Article
- Skin-derived dendritic cells (DCs) include Langerhans cells, classical dermal DCs and a langerin-positive CD103(+) dermal subset. We examined their involvement in the presentation of skin-associated viral and self antigens. Only the CD103(+) subset efficiently presented antigens of herpes simplex virus type 1 to naive CD8(+) T cells, although all subsets presented these antigens to CD4(+) T cells. This showed that CD103+ DCs were the migratory subset most efficient at processing viral antigens into the major histocompatibility complex class I pathway, potentially through cross-presentation. This was supported by data showing only CD103(+) DCs efficiently cross-presented skin-derived self antigens. This indicates CD103(+) DCs are the main migratory subtype able to cross-present viral and self antigens, which identifies another level of specialization for skin DCs.
- NATURE PUBLISHING GROUP
- HERPES-SIMPLEX-VIRUS; CD8(+) T-CELLS; LANGERHANS CELLS; IN-VIVO; CUTTING EDGE; STEADY-STATE; CONTACT HYPERSENSITIVITY; LYMPH-NODES; IMMUNITY; INFECTION
- Publisher's Version
- Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2009-05-01 12:00:00Last Modified: 0001-01-01 12:00:00