Cross-presentation of viral and self antigens by skin-derived CD103(+) dendritic cells
Details
Publication Year 2009-05, Volume 10, Issue #5, Page 488-495
Journal Title
NATURE IMMUNOLOGY
Publication Type
Journal Article
Abstract
Skin-derived dendritic cells (DCs) include Langerhans cells, classical dermal DCs and a langerin-positive CD103(+) dermal subset. We examined their involvement in the presentation of skin-associated viral and self antigens. Only the CD103(+) subset efficiently presented antigens of herpes simplex virus type 1 to naive CD8(+) T cells, although all subsets presented these antigens to CD4(+) T cells. This showed that CD103+ DCs were the migratory subset most efficient at processing viral antigens into the major histocompatibility complex class I pathway, potentially through cross-presentation. This was supported by data showing only CD103(+) DCs efficiently cross-presented skin-derived self antigens. This indicates CD103(+) DCs are the main migratory subtype able to cross-present viral and self antigens, which identifies another level of specialization for skin DCs.
Publisher
NATURE PUBLISHING GROUP
Keywords
HERPES-SIMPLEX-VIRUS; CD8(+) T-CELLS; LANGERHANS CELLS; IN-VIVO; CUTTING EDGE; STEADY-STATE; CONTACT HYPERSENSITIVITY; LYMPH-NODES; IMMUNITY; INFECTION
Publisher's Version
https://doi.org/10.1038/ni.1724
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2009-05-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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