Enhancing immune responses by targeting antigen to DC
Details
Publication Year 2009-04, Volume 39, Issue #4, Page 931-938
Journal Title
EUROPEAN JOURNAL OF IMMUNOLOGY
Publication Type
Journal Article
Abstract
mAb that recognise various cell surface receptors have been used to deliver antigen to DC and thereby elicit immune responses. The encouraging data obtained in mouse models suggests that this immunisation strategy is efficient and could lead to clinical trials. We discuss a number of issues pertinent to this vaccination approach. These include which molecules are the best targets for delivering antigen to DC, which DC subtypes should be targeted, the types of immune responses to be generated and whether additional adjuvants are required. Finally, we discuss some progress towards targeting antigen to human DC.
Publisher
WILEY-V C H VERLAG GMBH
Keywords
T-CELL RESPONSES; HUMAN DENDRITIC CELLS; C-TYPE LECTIN; MONOCLONAL-ANTIBODY NLDC-145; FOLLICULAR-HELPER-CELLS; SUBSETS IN-VIVO; STEADY-STATE; CROSS-PRESENTATION; TISSUE DISTRIBUTION; DEC-205 RECEPTOR
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2009-04-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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