Enhancing immune responses by targeting antigen to DC
- Author(s)
- Caminschi, I; Lahoud, MH; Shortman, K;
- Details
- Publication Year 2009-04,Volume 39,Issue #4,Page 931-938
- Journal Title
- EUROPEAN JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- mAb that recognise various cell surface receptors have been used to deliver antigen to DC and thereby elicit immune responses. The encouraging data obtained in mouse models suggests that this immunisation strategy is efficient and could lead to clinical trials. We discuss a number of issues pertinent to this vaccination approach. These include which molecules are the best targets for delivering antigen to DC, which DC subtypes should be targeted, the types of immune responses to be generated and whether additional adjuvants are required. Finally, we discuss some progress towards targeting antigen to human DC.
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- T-CELL RESPONSES; HUMAN DENDRITIC CELLS; C-TYPE LECTIN; MONOCLONAL-ANTIBODY NLDC-145; FOLLICULAR-HELPER-CELLS; SUBSETS IN-VIVO; STEADY-STATE; CROSS-PRESENTATION; TISSUE DISTRIBUTION; DEC-205 RECEPTOR
- Publisher's Version
- https://doi.org/10.1002/eji.200839035
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2009-04-01 12:00:00