Antigen presentation by dendritic cells in vivo
- Author(s)
- Segura, E; Villadangos, JA;
- Details
- Publication Year 2009-02,Volume 21,Issue #1,Page 105-110
- Journal Title
- CURRENT OPINION IN IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Dendritic cells (DC) are heterogenous, comprising several subpopulations of migratory and lymphoid-organ-resident types. Recent studies addressing the role of each subset in antigen presentation in vivo have revealed a complex division of labor within the DC network. In addition to CD8(+) DC, migratory lung or dermal DC can cross-present antigen in vivo. Migratory DC also transport to the lymph nodes antigens that can be transferred to resident DC for presentation. In inflammatory conditions, the antigen-presentation abilities of DC can be severely impaired, but an additional population of monocyte-derived DC then comes into play. Understanding the contribution of each DC subset to a physiological immune response is particularly relevant for rational vaccine design.
- Publisher
- CURRENT BIOLOGY LTD
- Keywords
- BRONCHIAL LYMPH-NODE; CD8(+) T-CELLS; LANGERHANS CELLS; CROSS-PRESENTATION; CUTTING EDGE; STEADY-STATE; MOUSE THYMUS; BONE-MARROW; INFECTION; POPULATIONS
- Publisher's Version
- https://doi.org/10.1016/j.coi.2009.03.011
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2009-02-01 12:00:00