'Knock, and it shall be opened': Knocking out and knocking in to reveal mechanisms of disease and novel therapies
- Author(s)
- Hacking, DF;
- Details
- Publication Year 2008-12,Volume 84,Issue #12,Page 821-827
- Journal Title
- EARLY HUMAN DEVELOPMENT
- Publication Type
- Journal Article
- Abstract
- Recent significant advances in molecular biology have generated genetically modified bacteria, yeast, nematodes, fruit flies, and fish. However, it is the genetic modification of mammalian model organisms, particularly the mouse, that has the greatest potential to shed light on human development, physiology and pathology in ways that have significant implications for neonatal and paediatric clinical practice. Here, we review some of the techniques for knocking out (inactivating), mutating and knocking in (inserting) selected genes that are important to neonatology and show how this research will lead both to a better understanding of disease and to novel therapies for infants and children. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- NOBEL-PRIZE; STEM-CELLS; MOUSE; MUTATIONS; MICE
- Publisher's Version
- https://doi.org/10.1016/j.earlhumdev.2008.09.011
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2008-12-01 12:00:00