The impact of circulating dendritic cells on the development and differentiation of thymocytes
- Author(s)
- Proietto, AI; van Dommelen, S; Wu, L;
- Details
- Publication Year 2009-01,Volume 87,Issue #1,Page 39-45
- Journal Title
- IMMUNOLOGY AND CELL BIOLOGY
- Publication Type
- Journal Article
- Abstract
- Central tolerance is established through the negative selection of self-reactive thymocytes and the induction of T-regulatory cells (T-regs). A role for thymic epithelial cells in mediating both negative selection and T-reg induction has been clearly shown. The role of thymic dendritic cells (DCs) in these processes has not been clearly determined but has been the focus of recent studies. Thymic DCs include two conventional DC (cDC) subtypes, CD8(lo)Sirp alpha(hi/+) (CD8(lo)Sirp alpha(+) herein) and CD8(hi)Sirp alpha(lo/-) (CD8(hi)Sirp alpha(-) herein). It has been shown that these DC subsets have distinct developmental origins, the CD8(hi)Sirp alpha(-) cDCs developing intra-thymically and the CD8(lo)Sirp alpha(+) migrating into the thymus from the periphery. Furthermore, an important role for thymic DCs in the induction of T-regs has been shown. In this review, the role of DCs in the development and education of T cells in the thymus will be reviewed, with emphasis on the role of circulatory DCs in mediating these processes.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- REGULATORY T-CELLS; THYMIC EPITHELIAL-CELLS; IMMUNOLOGICAL SELF-TOLERANCE; RECEPTOR TRANSGENIC MICE; MAJOR HISTOCOMPATIBILITY COMPLEX; CLONAL DELETION; NEGATIVE SELECTION; POSITIVE SELECTION; IN-VIVO; MOUSE THYMUS
- Publisher's Version
- https://doi.org/10.1038/icb.2008.86
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2009-01-01 12:00:00