Synthesis of Azide-alkyne Fragments for &#39;Click&#39; Chemical Applications. Formation of Chiral 1,4-Disubstituted-(beta-alkyl)-gamma-1,2,3-triazole Scaffolds from Orthogonally Protected Chiral beta-Alkyl-trialkylsilyl-gamma-pentynyl Azides and Chiral beta-Alkyl-gamma-pentynyl-alcohols

Montagnat, OD; Lessene, G; Hughes, AB

Synthesis of Azide-alkyne Fragments for 'Click' Chemical Applications. Formation of Chiral 1,4-Disubstituted-(beta-alkyl)-gamma-1,2,3-triazole Scaffolds from Orthogonally Protected Chiral beta-Alkyl-trialkylsilyl-gamma-pentynyl Azides and Chiral beta-Alkyl-gamma-pentynyl-alcohols

Author(s): Montagnat, OD; Lessene, G; Hughes, AB;
Details: Publication Year 2010,Volume 63,Issue #11,Page 1541-1549
Journal Title: AUSTRALIAN JOURNAL OF CHEMISTRY
Publication Type: Journal Article
Abstract: A library of chiral gamma-pentynyl alcohols and gamma-pentynyl azides was made using the SuperQuat auxiliary. Coupling of the free alkynes with the azides by Huisgen 1,3-dipolar cycloaddition provided chiral oligomeric 1,4-disubstituted-1,2,3-triazolesas possible peptidomimetic compounds.
Publisher: CSIRO PUBLISHING
Keywords: OLIGOMERS; AUXILIARIES; FOLDAMERS; 5,5-DIMETHYL-4-ISO-PROPYLOXAZOLIDIN-2-ONE; TRIFLUOROMETHANESULFONATES; OXAZOLIDIN-2-ONES; ALKYLATIONS; CHEMISTRY; DISCOVERY; AMINO
Publisher's Version: https://doi.org/10.1071/CH10306
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2010-01-01 12:00:00