Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis
- Author(s)
- Visvader, JE;
- Details
- Publication Year 2009-11-15,Volume 23,Issue #22,Page 2563-2577
- Journal Title
- GENES & DEVELOPMENT
- Publication Type
- Journal Article
- Abstract
- The epithelium of the mammary gland exists in a highly dynamic state, undergoing dramatic morphogenetic changes during puberty, pregnancy, lactation, and regression. The recent identification of stem and progenitor populations in mouse and human mammary tissue has provided evidence that the mammary epithelium is organized in a hierarchical manner. Characterization of these normal epithelial subtypes is an important step toward understanding which cells are predisposed to oncogenesis. This review summarizes progress in the field toward defining constituent cells and key molecular regulators of the mammary epithelial hierarchy. Potential relationships between normal epithelial populations and breast tumor subtypes are discussed, with implications for understanding the cellular etiology underpinning breast tumor heterogeneity.
- Publisher
- COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
- Keywords
- ESTROGEN-RECEPTOR-ALPHA; TEMPLATE DNA STRANDS; STEM-CELL ACTIVITY; ADULT HUMAN BREAST; IN-VIVO; PROGENITOR CELLS; GLAND DEVELOPMENT; STEM/PROGENITOR CELLS; LIFE SPAN; SERIAL TRANSPLANTATION
- Publisher's Version
- https://doi.org/10.1101/gad.1849509
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2009-11-15 12:00:00