The Tasmanian Devil Transcriptome Reveals Schwann Cell Origins of a Clonally Transmissible Cancer
- Murchison, EP; Tovar, C; Hsu, A; Bender, HS; Kheradpour, P; Rebbeck, CA; Obendorf, D; Conlan, C; Bahlo, M; Blizzard, CA; Pyecroft, S; Kreiss, A; Kellis, M; Stark, A; Harkins, TT; Graves, JAM; Woods, GM; Hannon, GJ; Papenfuss, AT;
Publication Year 2010-01-01, Volume 327, Issue #5961, Page 84-87
- Journal Title
- Publication Type
- Journal Article
- The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD with microsatellite genotyping, a mitochondrial genome analysis, and deep sequencing of the DFTD transcriptome and microRNAs. These studies confirm that DFTD is a monophyletic clonally transmissible tumor and suggest that the disease is of Schwann cell origin. On the basis of these results, we have generated a diagnostic marker for DFTD and identify a suite of genes relevant to DFTD pathology and transmission. We provide a genomic data set for the Tasmanian devil that is applicable to cancer diagnosis, disease evolution, and conservation biology.
- AMER ASSOC ADVANCEMENT SCIENCE
- FACIAL-TUMOR DISEASE; SARCOPHILUS-HARRISII; IMMUNOHISTOCHEMICAL CHARACTERIZATION; VENEREAL TUMOR; MICRORNAS; DIVERSITY; NEOPLASMS; EVOLUTION; PROTEIN; SYSTEM
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Creation Date: 2010-01-01 12:00:00Last Modified: 0001-01-01 12:00:00