Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2

Author(s): Kiu, H; Greenhalgh, CJ; Thaus, A; Hilton, DJ; Nicola, NA; Alexander, WS; Roberts, AW;
Details: Publication Year 2009-12,Volume 27,Issue #6,Page 384-393
Journal Title: GROWTH FACTORS
Publication Type: Journal Article
Abstract: Suppressor of cytokine signalling (SOCS) 3 is an essential regulator of cytokine signalling, and in turn its expression is tightly regulated. Data from overexpression studies in cell lines suggest that SOCS2 regulates SOCS3 protein degradation, by forming a molecular bridge to an E3 ubiquitin-ligase complex. Whether this regulation is relevant in primary cells is unknown. In this study, we utilized Socs2(-/-) mice to examine the role of SOCS2 in modulating SOCS3 expression and degradation, and its impact on interleukin-2 (IL-2) and IL-6 signalling in primary haemopoietic cells. Both biochemical and biological analyses demonstrated unperturbed SOCS3 expression and cytokine signalling in the absence of SOCS2. Our results suggest that SOCS2 is not a physiological regulator of SOCS3 expression and action in primary haemopoietic cells.
Publisher: INFORMA HEALTHCARE
Publisher's Version: https://doi.org/10.3109/08977190903210954
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2009-12-01 12:00:00