IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
Details
Publication Year 2009-10, Volume 41, Issue #10, Page 1100-U74
Journal Title
NATURE GENETICS
Publication Type
Journal Article
Abstract
Hepatitis C virus (HCV) infects 3% of the world's population. Treatment of chronic HCV consists of a combination of PEGylated interferon-alpha (PEG-IFN-alpha) and ribavirin (RBV). To identify genetic variants associated with HCV treatment response, we conducted a genome-wide association study of sustained virological response (SVR) to PEG-IFN-alpha/RBV combination therapy in 293 Australian individuals with genotype 1 chronic hepatitis C, with validation in an independent replication cohort consisting of 555 individuals. We report an association to SVR within the gene region encoding interleukin 28B (IL28B, also called IFN lambda 3; rs8099917 combined P = 9.25 x 10(-9), OR = 1.98, 95% CI = 1.57-2.52). IL28B contributes to viral resistance and is known to be upregulated by interferons and by RNA virus infection. These data suggest that host genetics may be useful for the prediction of drug response, and they also support the investigation of the role of IL28B in the treatment of HCV and in other diseases treated with IFN-alpha.
Publisher
NATURE PUBLISHING GROUP
Keywords
GENOME-WIDE ASSOCIATION; GENE-EXPRESSION; ANTIVIRAL ACTIVITY; VIRUS-REPLICATION; RANDOMIZED-TRIAL; PLUS RIBAVIRIN; IFN-LAMBDA; III IFN; INFECTION; OPINION
Publisher's Version
https://doi.org/10.1038/ng.447
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2009-10-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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