IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
- Suppiah, V; Moldovan, M; Ahlenstiel, G; Berg, T; Weltman, M; Abate, ML; Bassendine, M; Spengler, U; Dore, GJ; Powell, E; Riordan, S; Sheridan, D; Smedile, A; Fragomeli, V; Muller, T; Bahlo, M; Stewart, GJ; Booth, DR; George, J;
Publication Year 2009-10, Volume 41, Issue #10, Page 1100-U74
- Journal Title
- NATURE GENETICS
- Publication Type
- Journal Article
- Hepatitis C virus (HCV) infects 3% of the world's population. Treatment of chronic HCV consists of a combination of PEGylated interferon-alpha (PEG-IFN-alpha) and ribavirin (RBV). To identify genetic variants associated with HCV treatment response, we conducted a genome-wide association study of sustained virological response (SVR) to PEG-IFN-alpha/RBV combination therapy in 293 Australian individuals with genotype 1 chronic hepatitis C, with validation in an independent replication cohort consisting of 555 individuals. We report an association to SVR within the gene region encoding interleukin 28B (IL28B, also called IFN lambda 3; rs8099917 combined P = 9.25 x 10(-9), OR = 1.98, 95% CI = 1.57-2.52). IL28B contributes to viral resistance and is known to be upregulated by interferons and by RNA virus infection. These data suggest that host genetics may be useful for the prediction of drug response, and they also support the investigation of the role of IL28B in the treatment of HCV and in other diseases treated with IFN-alpha.
- NATURE PUBLISHING GROUP
- GENOME-WIDE ASSOCIATION; GENE-EXPRESSION; ANTIVIRAL ACTIVITY; VIRUS-REPLICATION; RANDOMIZED-TRIAL; PLUS RIBAVIRIN; IFN-LAMBDA; III IFN; INFECTION; OPINION
- Publisher's Version
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Creation Date: 2009-10-01 12:00:00Last Modified: 0001-01-01 12:00:00