G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis
Details
Publication Year 2009-10, Volume 5, Issue #10, Page 554-559
Journal Title
NATURE REVIEWS RHEUMATOLOGY
Publication Type
Journal Article
Abstract
Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are well-recognized regulators of hematopoiesis and have an established role as growth factors in clinical practice. G-CSF and GM-CSF regulate myeloid cell production, differentiation and activation, and might also be important for driving inflammatory responses. Inappropriate engagement of this pathway could be a critical amplification mechanism when maladaptive immune responses predispose to autoimmunity and sterile tissue inflammation. We postulate that antagonism of G-CSF or GM-CSF could represent a novel therapeutic approach for a variety of autoimmune-mediated inflammatory diseases, including rheumatoid arthritis.
Publisher
NATURE PUBLISHING GROUP
Keywords
COLONY-STIMULATING FACTOR; PULMONARY ALVEOLAR PROTEINOSIS; BLOOD NEUTROPHIL COUNTS; INFLAMMATORY ARTHRITIS; DEFICIENT MICE; APOPTOTIC NEUTROPHILS; ANTIRHEUMATIC DRUGS; OPPOSING ACTIONS; SYNOVIAL-FLUID; EFFECTOR PHASE
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2009-10-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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