G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis

Author(s): Cornish, AL; Campbell, IK; McKenzie, BS; Chatfield, S; Wicks, IP;
Details: Publication Year 2009-10,Volume 5,Issue #10,Page 554-559
Journal Title: NATURE REVIEWS RHEUMATOLOGY
Publication Type: Journal Article
Abstract: Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are well-recognized regulators of hematopoiesis and have an established role as growth factors in clinical practice. G-CSF and GM-CSF regulate myeloid cell production, differentiation and activation, and might also be important for driving inflammatory responses. Inappropriate engagement of this pathway could be a critical amplification mechanism when maladaptive immune responses predispose to autoimmunity and sterile tissue inflammation. We postulate that antagonism of G-CSF or GM-CSF could represent a novel therapeutic approach for a variety of autoimmune-mediated inflammatory diseases, including rheumatoid arthritis.
Publisher: NATURE PUBLISHING GROUP
Keywords: COLONY-STIMULATING FACTOR; PULMONARY ALVEOLAR PROTEINOSIS; BLOOD NEUTROPHIL COUNTS; INFLAMMATORY ARTHRITIS; DEFICIENT MICE; APOPTOTIC NEUTROPHILS; ANTIRHEUMATIC DRUGS; OPPOSING ACTIONS; SYNOVIAL-FLUID; EFFECTOR PHASE
Publisher's Version: https://doi.org/10.1038/nrrheum.2009.178
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2009-10-01 12:00:00