Cutting Edge: B220(+)CCR9(-) Dendritic Cells Are Not Plasmacytoid Dendritic Cells but Are Precursors of Conventional Dendritic Cells

Author(s): Segura, E; Wong, J; Villadangos, JA;
Details: Publication Year 2009-08-01,Volume 183,Issue #3,Page 1514-1517
Journal Title: JOURNAL OF IMMUNOLOGY
Publication Type: Journal Article
Abstract: Mouse lymphoid organs contain two major subsets of dendritic cells (DC) that differ in their phenotype and functions: conventional DC (cDC) and plasmacytoid DC (pDC). Recently, it has been proposed that differential expression of CCR9 could distinguish functionally distinct pDC subsets. We show that B220(+)CCR9(-) DC do not express classical pDC markers and have a developmental origin different from that of pDC. Furthermore, B220(+)CCR9(-) DC do not secrete IFN-alpha in response to CpG and, unlike pDC, can efficiently present exogenous Ags. Our results demonstrate that B220(+)CCR9(-) DC do not represent a subset of pDC. After in vivo transfer, these cells down-regulate B220 expression and convert into the two major cDC subsets, showing that they are a developmental stage of cDC differentiation. The Journal of Immunology, 2009, 183:1514-1517.
Publisher: AMER ASSOC IMMUNOLOGISTS
Keywords: IIFN-PRODUCING CELLS; IN-VIVO; ANTIGEN-PRESENTATION; STEADY-STATE; EXPRESSION; MOUSE; DISTINCT
Publisher's Version: https://doi.org/10.4049/jimmunol.0901524
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2009-08-01 12:00:00