Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
Details
Publication Year 2009-07, Volume 41, Issue #7, Page 824-U84
Journal Title
NATURE GENETICS
Publication Type
Journal Article
Abstract
To identify multiple sclerosis (MS) susceptibility loci, we conducted a genome-wide association study (GWAS) in 1,618 cases and used shared data for 3,413 controls. We performed replication in an independent set of 2,256 cases and 2,310 controls, for a total of 3,874 cases and 5,723 controls. We identified risk-associated SNPs on chromosome 12q13-14 (rs703842, P = 5.4 x 10(-11); rs10876994, P = 2.7 x 10(-10); rs12368653, P = 1.0 x 10(-7)) and upstream of CD40 on chromosome 20q13 (rs6074022, P = 1.3 x 10(-7); rs1569723, P = 2.9 x 10(-7)). Both loci are also associated with other autoimmune diseases(1-5). We also replicated several known MS associations (HLA-DR15, P = 7.0 x 10(-184); CD58, P = 9.6 x 10(-8); EVI5-RPL5, P = 2.5 x 10(-6); IL2RA, P = 7.4 x 10(-6); CLEC16A, P = 1.1 x 10(-4); IL7R, P = 1.3 x 10(-3); TYK2, P = 3.5 x 10(-3)) and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15 (P = 0.001).
Publisher
NATURE PUBLISHING GROUP
Keywords
RHEUMATOID-ARTHRITIS; DIAGNOSTIC-CRITERIA; CD40; ENCEPHALOMYELITIS; DIFFERENTIATION; POLYMORPHISM; EXPRESSION; GUIDELINES; INDUCTION; INFERENCE
Publisher's Version
https://doi.org/10.1038/ng.396
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2009-07-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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