Swift: primary data analysis for the Illumina Solexa sequencing platform
Details
Publication Year 2009-09-01, Volume 25, Issue #17, Page 2194-2199
Journal Title
BIOINFORMATICS
Publication Type
Journal Article
Abstract
Motivation: Primary data analysis methods are of critical importance in second generation DNA sequencing. Improved methods have the potential to increase yield and reduce the error rates. Openly documented analysis tools enable the user to understand the primary data, this is important for the optimization and validity of their scientific work. Results: In this article, we describe Swift, a new tool for performing primary data analysis on the Illumina Solexa Sequencing Platform. Swift is the first tool, outside of the vendors own software, which completes the full analysis process, from raw images through to base calls. As such it provides an alternative to, and independent validation of, the vendor supplied tool. Our results show that Swift is able to increase yield by 13.8%, at comparable error rate.
Publisher
OXFORD UNIV PRESS
Keywords
MICROARRAYS
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2009-09-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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