Towards understanding epithelial-mesenchymal transition: A proteomics perspective
Author(s)
Mathias, RA; Simpson, RJ;
Details
Publication Year 2009-09, Volume 1794, Issue #9, Page 1325-1331
Journal Title
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
Publication Type
Journal Article
Abstract
Epithelial-mesenchymal transition (EMT) is recognised as a crucial embryonic process that converts immotile epithelial cells into migratory mesenchymal cells. More recently, EMT has been implicated in key stages of turnout progression, whereby it facilitates epithelial cancer cell metastasis. Traditionally, molecular and cell biology-based approaches have been utilised to study EMT. However, a recent wave of EMT research has implemented proteomic techniques to reveal new insights, and these integrated strategies have implicated novel proteins in the process of EMT. In this review, we highlight the important contributions proteomics has made in broadening our existing knowledge of EMT. Recent advances in sub-proteome sample preparation, proteomic tools including mass spectrometry instrumentation and protein quantitation, will further refine and extend our understanding of the cellular EMT process. (C) 2009 Elsevier B.V. All rights reserved.
Publisher
ELSEVIER SCIENCE BV
Keywords
E-CADHERIN EXPRESSION; BREAST-CANCER CELLS; MASS-SPECTROMETRY; TUMOR PROGRESSION; SYSTEMS BIOLOGY; QUANTITATIVE PROTEOMICS; GEL-ELECTROPHORESIS; CARCINOMA CELLS; SCATTER FACTOR; METASTASIS
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2009-09-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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