Memory B cells: Effectors of long-lived immune responses

Author(s): Tangye, SG; Tarlinton, DM;
Details: Publication Year 2009-08,Volume 39,Issue #8,Page 2065-2075
Journal Title: EUROPEAN JOURNAL OF IMMUNOLOGY
Publication Type: Journal Article
Abstract: Immunological memory is the phenomenon whereby B and T cells have the unique ability to respond with heightened kinetics and efficacy to subsequent encounter with Ag relative to the initial exposure. in this review, we examine recent developments in the phenotypic characterisation. of memory B cells, with an emphasis on the definition and functional properties of memory B-cell subsets in humans. Gene expression differences are also considered in light of the unique functional and survival properties of memory B cells, and mutations that alter memory formation and function are also examined. Finally, we consider recent advances in the understanding of germinal center B-cell differentiation through analysis of transcription factor networks operating in these B cells.
Publisher: WILEY-BLACKWELL
Keywords: INDUCED CYTIDINE DEAMINASE; GERMINAL CENTER REACTION; IG-SECRETING CELLS; LINKED LYMPHOPROLIFERATIVE DISEASE; CLASS-SWITCH RECOMBINATION; VARIABLE REGION GENES; MARGINAL ZONE; CUTTING EDGE; HUMAN SPLEEN; TERMINAL DIFFERENTIATION
Publisher's Version: https://doi.org/10.1002/eji.200939531
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2009-08-01 12:00:00