Blimp-1 Transcription Factor Is Required for the Differentiation of Effector CD8(+) T Cells and Memory Responses
- Author(s)
- Kallies, A; Xin, A; Belz, GT; Nutt, SL;
- Details
- Publication Year 2009-08-21,Volume 31,Issue #2,Page 283-295
- Journal Title
- IMMUNITY
- Publication Type
- Journal Article
- Abstract
- In response to viral infection, naive CD8(+) T cells proliferate and differentiate into cytotoxic and cytokine-producing effector cells. Here we showed that the transcription factor Blimp-1, a crucial regulator of plasma cell differentiation, was required for CD8(+) T cells to differentiate into functional killer T cells in response to influenza virus. Blimp-1 was not essential for the generation of memory T cells but was crucial for their efficient recall response upon reinfection. Antigen-specific Blimp-1-deficient CD8(+) T cells failed to appropriately regulate the transcriptional program essential for killer T cell responses and showed impaired migration to the site of infection. This study identifies Blimp-1 as a master regulator of the terminal differentiation of CD8(+) effector T cells and uncovers a conservation of the pathways that regulate the terminal differentiation of T and B cells.
- Publisher
- CELL PRESS
- Keywords
- TERMINAL DIFFERENTIATION; LYMPHOCYTE DIVISION; REPRESSOR BLIMP-1; B-CELLS; EXPRESSION; INFLUENZA; BET; EOMESODERMIN; HOMEOSTASIS; ACTIVATION
- Publisher's Version
- https://doi.org/10.1016/j.immuni.2009.06.021
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2009-08-21 12:00:00