ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays
Author(s)
Hu, YF; Smyth, GK;
Details
Publication Year 2009-08-15, Volume 347, Issue #1-2, Page 70-78
Journal Title
JOURNAL OF IMMUNOLOGICAL METHODS
Publication Type
Journal Article
Abstract
ELDA is a software application for limiting dilution analysis (LIDA), with particular attention to the needs of stem cell assays. It is the first limiting dilution analysis software to provide meaningful confidence intervals for all LIDA data sets, including those with 0% or 100% responses. Other features include a test of the adequacy of the single-hit hypothesis, tests for frequency differences between multiple data sets, and the ability to take advantage of cases where the number of cells in the sample is counted exactly. A webtool at http://bioinf.wehi.edu.au/software/elda/ provides an easy user interface. (C) 2009 Elsevier B.V. All rights reserved.
Publisher
ELSEVIER SCIENCE BV
Keywords
HIT POISSON MODEL; GENERALIZED LINEAR-MODELS; BONE-MARROW; CANCER; DIFFERENTIATION; GENERATION; IDENTIFICATION; FREQUENCIES; TESTS; BLOOD
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2009-08-15 12:00:00
Last Modified: 0001-01-01 12:00:00
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