The Molecular Signature of Tissue Resident Memory CD8 T Cells Isolated from the Brain
Details
Publication Year 2012-10-01, Volume 189, Issue #7, Page 3462-3471
Journal Title
JOURNAL OF IMMUNOLOGY
Publication Type
Journal Article
Abstract
Tissue resident memory (Trm) CD8 T cells represent a newly described memory T cell population. We have previously characterized a population of Trmcells that persists within the brain after acute virus infection. Although capable of providing marked protection against a subsequent local challenge, brain Trm cells do not undergo recall expansion after dissociation from the tissue. Furthermore, these Trm cells do not depend on the same survival factors as the circulating memory T cell pool as assessed either in vivo or in vitro. To gain greater insight into this population of cells, we compared the gene expression profiles of Trm cells isolated from the brain with those of circulating memory T cells isolated from the spleen after an acute virus infection. Trm cells displayed altered expression of genes involved in chemotaxis, expressed a distinct set of transcription factors, and overexpressed several inhibitory receptors. Cumulatively, these data indicate that Trmcells are a distinct memory T cell population disconnected from the circulating memory T cell pool and display a unique molecular signature that likely results in optimal survival and function within their local environment. The Journal of Immunology, 2012, 189: 3462-3471.
Publisher
AMER ASSOC IMMUNOLOGISTS
Keywords
HERPES-SIMPLEX-VIRUS; WEST-NILE-VIRUS; NONLYMPHOID TISSUE; INFECTION; LYMPHOCYTES; EXPRESSION; IMMUNITY; ABSENCE
WEHI Research Division(s)
Inflammation; Bioinformatics
Rights Notice
Copyright © 2012 by The American Association of Immunologists, Inc.


Creation Date: 2012-10-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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