The cellular and molecular basis for malaria parasite invasion of the human red blood cell

Cowman, AF; Berry, D; Baum, J

Author(s): Cowman, AF; Berry, D; Baum, J;
Details: Publication Year 2012-09-17,Volume 198,Issue #6,Page 961-971
Journal Title: JOURNAL OF CELL BIOLOGY
Publication Type: Journal Article
Abstract: Malaria is a major disease of humans caused by protozoan parasites from the genus Plasmodium. It has a complex life cycle; however, asexual parasite infection within the blood stream is responsible for all disease pathology. This stage is initiated when merozoites, the free invasive blood-stage form, invade circulating erythrocytes. Although invasion is rapid, it is the only time of the life cycle when the parasite is directly exposed to the host immune system. Significant effort has, therefore, focused on identifying the proteins involved and understanding the underlying mechanisms behind merozoite invasion into the protected niche inside the human erythrocyte.
Publisher: ROCKEFELLER UNIV PRESS
Keywords: PLASMODIUM-FALCIPARUM MEROZOITES; APICAL MEMBRANE ANTIGEN; ERYTHROCYTE BINDING ANTIGEN; HOST-CELL; SURFACE PROTEIN-1; APICOMPLEXAN PARASITES; MOVING JUNCTION; TOXOPLASMA-GONDII; STAGE MALARIA; GLYCOPHORIN-C
Research Division(s): Infection And Immunity
Publisher's Version: https://doi.org/10.1083/jcb.201206112
Open Access at Publisher's Site: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444787/
Terms of Use/Rights Notice: Copyright © 2012 Cowman et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

Creation Date: 2012-09-17 12:00:00