Copy-number-aware differential analysis of quantitative DNA sequencing data
- Author(s)
- Robinson, MD; Strbenac, D; Stirzaker, C; Statham, AL; Song, J; Speed, TP; Clark, SJ;
- Details
- Publication Year 2012-12,Volume 22,Issue #12,Page 2489-2496
- Journal Title
- GENOME RESEARCH
- Publication Type
- Journal Article
- Abstract
- Developments in microarray and high-throughput sequencing (HTS) technologies have resulted in a rapid expansion of research into epigenomic changes that occur in normal development and in the progression of disease, such as cancer. Not surprisingly, copy number variation (CNV) has a direct effect on HTS read densities and can therefore bias differential detection results. We have developed a flexible approach called ABCD-DNA (affinity-based copy-number-aware differential quantitative DNA sequencing analyses) that integrates CNV and other systematic factors directly into the differential enrichment engine.
- Publisher
- COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
- Research Division(s)
- Bioinformatics
- Link To PubMed Central Version
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514678/
- Publisher's Version
- https://doi.org/10.1101/gr.139055.112
- Open Access at Publisher's Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514678/- Terms of Use/Rights Notice
- © 2012, Published by Cold Spring Harbor Laboratory Press This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported License), as described at http://creativecommons.org/licenses/by-nc/3.0/
Creation Date: 2012-12-01 12:00:00