Determination of protein subcellular localization in apicomplexan parasites
- Author(s)
- Woodcroft, BJ; McMillan, PJ; Dekiwadia, C; Tilley, L; Ralph, SA;
- Details
- Publication Year 2012-12,Volume 28,Issue #12,Page 546-554
- Journal Title
- TRENDS IN PARASITOLOGY
- Publication Type
- Journal Article
- Abstract
- Parasites from the phylum Apicomplexa include causative agents of serious diseases including malaria (Plasmodium spp.) and toxoplasmosis (Toxoplasma gondii). Apicomplexan parasites infect thousands of types of animal cells and send their proteins to an array of compartments within their own cell, as well as exporting proteins into and beyond their host cell. Ascertaining destinations to which individual proteins are delivered allows researchers to better understand parasite biology and to identify potential targets for therapeutic interventions. Our toolkit for establishing subcellular locations of apicomplexan proteins is becoming more extensive and specialized, and here we review developments in this technology.
- Publisher
- ELSEVIER SCI LTD
- Research Division(s)
- Bioinformatics
- Publisher's Version
- https://doi.org/10.1016/j.pt.2012.08.008
- Terms of Use/Rights Notice
- Crown copyright © 2012 Published by Elsevier Ltd. All rights reserved
Creation Date: 2012-12-01 12:00:00