The Role of the Apoptotic Machinery in Tumor Suppression
- Author(s)
- Delbridge, ARD; Valente, LJ; Strasser, A;
- Details
- Publication Year 2012-11,Volume 4,Issue #11,Page a008789
- Journal Title
- COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
- Publication Type
- Journal Article
- Abstract
- Multicellular organisms have evolved processes to prevent abnormal proliferation or inappropriate tissue infiltration of cells, and these tumor suppressive mechanisms serve to prevent tissue hyperplasia, tumor development, and metastatic spread of tumors. These include potentially reversible processes such as cell cycle arrest and cellular senescence, as well as apoptotic cell death, which in contrast eliminates dangerous cells that may initiate tumor development. Tumor suppressive processes are organized as complex, extensive signaling networks, controlled by central "nodes." These "nodes" are prominent tumor suppressors, such as P53 or PTEN, whose loss is responsible for the development of the majority of human cancers. In this review we discuss the processes by which some of these prominent tumor suppressors trigger apoptotic cell death and how this process protects us from cancer development.
- Publisher
- COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
- Keywords
- NF-KAPPA-B; THYMIC LYMPHOMA DEVELOPMENT; ALPHA-INDUCED APOPTOSIS; BH3-ONLY PROTEINS PUMA; CELL-CYCLE ARREST; DNA-DAMAGE; BCL-2 FAMILY; EMBRYONIC LETHALITY; RETINOBLASTOMA PROTEIN; MDM2-DEFICIENT MICE
- Research Division(s)
- Molecular Genetics Of Cancer
- Publisher's Version
- https://doi.org/10.1101/cshperspect.a008789
- Terms of Use/Rights Notice
- Copyright © 2012 Cold Spring Harbor Laboratory Press; all rights reserved
Creation Date: 2012-11-01 12:00:00