Multiple routes to B-cell memory
- Author(s)
- Good-Jacobson, KL; Tarlinton, DM;
- Details
- Publication Year 2012-07,Volume 24,Issue #7,Page 403-408
- Journal Title
- INTERNATIONAL IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- B-cell memory describes the populations of cells that provide long-term humoral immunity: long-lived antibody-secreting plasma cells that reside mainly in the bone marrow and memory B cells. Interestingly, the memory B-cell population is heterogenous, although the importance of this heterogeneity has been unclear. Recent studies have investigated the formation and function of memory in different settings. In particular, T-independent memory-like cells and T-dependent (TD) IgM memory B cells qualitatively differ from canonical TD class-switched memory B cells; however, these studies suggest that IgM memory cells preserve the memory population over long periods of time. These subsets are evocative of the evolution of the humoral immune response, with memory-like cells appearing before acquisition of germinal centers, suggesting that there are multiple pathways to producing B-cell memory.
- Publisher
- OXFORD UNIV PRESS
- Keywords
- TORAFUGU TAKIFUGU-RUBRIPES; LIVED PLASMA-CELLS; GERMINAL-CENTERS; MURINE MEMORY; ANTIBODY-RESPONSES; SOMATIC MUTATION; IMMUNE-RESPONSE; GENE-EXPRESSION; T-CELLS; DIFFERENTIATION
- Research Division(s)
- Immunology
- Publisher's Version
- https://doi.org/10.1093/intimm/dxs050
- Terms of Use/Rights Notice
- Copyright © 2013 Japanese Society for Immunology
Creation Date: 2012-07-01 12:00:00