Multiple routes to B-cell memory
Details
Publication Year 2012-07, Volume 24, Issue #7, Page 403-408
Journal Title
INTERNATIONAL IMMUNOLOGY
Publication Type
Journal Article
Abstract
B-cell memory describes the populations of cells that provide long-term humoral immunity: long-lived antibody-secreting plasma cells that reside mainly in the bone marrow and memory B cells. Interestingly, the memory B-cell population is heterogenous, although the importance of this heterogeneity has been unclear. Recent studies have investigated the formation and function of memory in different settings. In particular, T-independent memory-like cells and T-dependent (TD) IgM memory B cells qualitatively differ from canonical TD class-switched memory B cells; however, these studies suggest that IgM memory cells preserve the memory population over long periods of time. These subsets are evocative of the evolution of the humoral immune response, with memory-like cells appearing before acquisition of germinal centers, suggesting that there are multiple pathways to producing B-cell memory.
Publisher
OXFORD UNIV PRESS
Keywords
TORAFUGU TAKIFUGU-RUBRIPES; LIVED PLASMA-CELLS; GERMINAL-CENTERS; MURINE MEMORY; ANTIBODY-RESPONSES; SOMATIC MUTATION; IMMUNE-RESPONSE; GENE-EXPRESSION; T-CELLS; DIFFERENTIATION
WEHI Research Division(s)
Immunology
Rights Notice
Copyright © 2013 Japanese Society for Immunology


Creation Date: 2012-07-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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