Functional regulation of monocyte-derived dendritic cells by microRNAs

Author(s): Zhan, YF; Wu, L;
Details: Publication Year 2012-07,Volume 3,Issue #7,Page 497-507
Journal Title: PROTEIN & CELL
Publication Type: Journal Article
Abstract: Dendritic cells (DCs) as a rare type of leukocytes play an important role in bridging the innate and adaptive immune system. A subset of DCs, monocyte-derived dendritic cells (moDCs), exists in very low numbers at steady state but become abundant in inflammatory states. These inflammation-associated DCs are potent producers of pro-inflammatory cytokines and potent inducers of T helper differentiation. They behave as a "double-edge" sword so that they not only mediate protective immunity but also immuno-pathology. It is still incompletely understood how their function is regulated. Emerging evidence indicates that microRNAs (miRNAs), as a new class of gene regulators, potently regulate the function of moDCs. Here we summarize recent progress in this area.
Publisher: HIGHER EDUCATION PRESS
Keywords: COLONY-STIMULATING FACTOR; TUMOR-NECROSIS-FACTOR; T-CELLS; IN-VIVO; LANGERHANS CELLS; GM-CSF; STEADY-STATE; BONE-MARROW; LISTERIA-MONOCYTOGENES; RECEPTOR EXPRESSION
Research Division(s): Immunology; Molecular Immunology
Publisher's Version: https://doi.org/10.1007/s13238-012-0042-0

Creation Date: 2012-07-01 12:00:00