Determining germinal centre B cell fate
- Author(s)
- Zotos, D; Tarlinton, DM;
- Details
- Publication Year 2012-06,Volume 33,Issue #6,Page 281-288
- Journal Title
- TRENDS IN IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- The humoral immune system generates immunological memory comprising affinity matured, long-lived memory B cells and plasma cells (PCs), which are generated primarily in germinal centres (GCs). Although many factors are essential in this process, those that specifically govern B cell fate are not fully understood. The provision of T cell help to B cells is key in GC B cell fate determination, and it has become clear recently that this help involves more than direct cell cell interactions. Recently, the cytokine interleukin (IL)-21 has been identified as a key factor that can modulate the processes within GCs and directly influence B cell fate. In this review, we examine the roles of GC cytokines in the context of cell differentiation.
- Publisher
- ELSEVIER SCI LTD
- Keywords
- memory; antibodies; affinity maturation; humoral immunity; cytokines
- Research Division(s)
- Immunology
- Publisher's Version
- https://doi.org/10.1016/j.it.2012.04.003
- Terms of Use/Rights Notice
- Copyright © 2012 Elsevier Ltd. All rights reserved.
Creation Date: 2012-06-01 12:00:00