Insulin-specific vaccination for type 1 diabetes A step closer?
- Author(s)
- Harrison, LC;
- Details
- Publication Year 2012-06,Volume 8,Issue #6,Page 834-837
- Journal Title
- HUMAN VACCINES & IMMUNOTHERAPEUTICS
- Publication Type
- Journal Article
- Abstract
- Vaccination against self-antigens to avert pathological immunity to self-'negative vaccination'-is the Holy Grail of autoimmune disease therapy. This approach depends on deletion or inactivation of pathogenic T cells, or induction of protective, 'regulatory' T cells. While effective in inbred rodent models, it is yet to be translated to humans. Reasons for this include its application only in end-stage disease, ignorance about antigen form, route of delivery and dose-schedule required for a bio-response, lack of meaningful and measurable bio-response markers, co-activation of pathogenic immunity and genetic heterogeneity.
- Publisher
- LANDES BIOSCIENCE
- Keywords
- BETA-CELL FUNCTION; RANDOMIZED CONTROLLED-TRIAL; ORAL TOLERANCE; T-CELLS; RISK; AUTOANTIBODIES; IMMUNIZATION; AUTOANTIGEN; PROINSULIN; RELATIVES
- Research Division(s)
- Molecular Medicine
- Publisher's Version
- https://doi.org/10.4161/hv.19673
- Terms of Use/Rights Notice
- © 2013 Landes Bioscience
Creation Date: 2012-06-01 12:00:00