Cancer Stem Cells: Current Status and Evolving Complexities
- Author(s)
- Visvader, JE; Lindeman, GJ;
- Details
- Publication Year 2012-06-14,Volume 10,Issue #6,Page 717-728
- Journal Title
- CELL STEM CELL
- Publication Type
- Journal Article
- Abstract
- The cancer stem cell (CSC) model has been established as a cellular mechanism that contributes to phenotypic and functional heterogeneity in diverse cancer types. Recent observations, however, have highlighted many complexities and challenges: the CSC phenotype can vary substantially between patients, tumors may harbor multiple phenotypically or genetically distinct CSCs, metastatic CSCs can evolve from primary CSCs, and tumor cells may undergo reversible phenotypic changes. Although the CSC concept will have clinical relevance in specific cases, accumulating evidence suggests that it will be imperative to target all CSC subsets within the tumor to prevent relapse.
- Publisher
- CELL PRESS
- Keywords
- TUMOR-INITIATING CELLS; ACUTE MYELOID-LEUKEMIA; HUMAN COLORECTAL-CANCER; MAINTAINS SELF-RENEWAL; PANCREATIC-CANCER; MELANOMA-CELLS; HUMAN BREAST; PHENOTYPIC HETEROGENEITY; PROPAGATING CELLS; VASCULAR NICHE
- Research Division(s)
- Stem Cells And Cancer
- Publisher's Version
- https://doi.org/10.1016/j.stem.2012.05.007
- Terms of Use/Rights Notice
- Copyright © 2012 Elsevier Inc. All rights reserved.
Creation Date: 2012-06-14 12:00:00