Adult lung stem cells and their contribution to lung tumourigenesis
- Author(s)
- Asselin-Labat, ML; Filby, CE;
- Journal Title
- OPEN BIOLOGY
- Publication Type
- Journal Article
- Abstract
- The isolation and characterization of lung stem and progenitor cells represent an important step towards the understanding of lung repair after injury, lung disease pathogenesis and the identification of the target cells of transformation in lung carcinogenesis. Different approaches using prospective isolation of progenitor cells by flow cytometry or lineage-tracing experiments in mouse models of lung injury have led to the identification of distinct progenitor subpopulations in different morphological regions of the adult lung. Genetically defined mouse models of lung cancer are offering new perspectives on the cells of origin of different subtypes of lung cancer. These mouse models pave the way to further investigate human lung progenitor cells at the origin of lung cancers, as well as to define the nature of the lung cancer stem cells. It will be critical to establish the link between oncogenic driver mutations recently discovered in lung cancers, target cells of transformation and subtypes of lung cancers to enable better stratification of patients for improved therapeutic strategies.
- Publisher
- ROYAL SOC
- Keywords
- ALVEOLAR TYPE-2 CELLS; SELF-RENEWAL; IN-VIVO; K-RAS; PROGENITOR CELLS; AIRWAY STEM; BASAL-CELLS; MOUSE LUNG; MELANOMA-CELLS; MAMMARY-GLAND
- Research Division(s)
- Stem Cells And Cancer
- Publisher's Version
- https://doi.org/10.1098/rsob.120094
- Open Access at Publisher's Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438537/- Terms of Use/Rights Notice
- © 2012 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.
Creation Date: 2012-08-01 12:00:00