Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation
- Author(s)
- van Gisbergen, KPJM; Kragten, NAM; Hertoghs, KML; Wensveen, FM; Jonjic, S; Hamann, J; Nolte, MA; van Lier, RAW;
- Details
- Publication Year 2012-09,Volume 13,Issue #9,Page 864-871
- Journal Title
- NATURE IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- The transcriptional repressor Blimp-1 mediates the terminal differentiation of many cell types, including T cells. Here we identified Hobit (Znf683) as a previously unrecognized homolog of Blimp-1 that was specifically expressed in mouse natural killer T cells (NKT cells). Through studies of Hobit-deficient mice, we found that Hobit was essential for the formation of mature thymic NKT cells. In the periphery, Hobit repressed the accumulation of interferon-gamma (IFN-gamma)-producing NK1.1(lo) NKT cells at steady state. After antigenic stimulation, Hobit repressed IFN-gamma expression, whereas after innate stimulation, Hobit induced granzyme B expression. Thus, reminiscent of the function of Blimp-1 in other lymphocytes, Hobit controlled the maintenance of quiescent, fully differentiated NKT cells and regulated their immediate effector functions.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- NK1(+) T-CELLS; NATURAL-KILLER; MICROBIAL INFECTION; CYTOKINE PRODUCTION; GENE-EXPRESSION; CUTTING EDGE; ACTIVATION; INTERFERON; MATURATION; LINEAGE
- Research Division(s)
- Molecular Immunology
- Publisher's Version
- https://doi.org/10.1038/ni.2393
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Creation Date: 2012-09-01 12:00:00