The regulation of the development and function of dendritic cell subsets by GM-CSF: More than a hematopoietic growth factor
- Details
- Publication Year 2012-08,Volume 52,Issue #1,Page 30-37
- Journal Title
- MOLECULAR IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Granulocyte-macrophage colony stimulating factor (GM-CSF) is a cytokine that functions as a hematopoietic growth factor for the generation of white blood cells and is used clinically to stimulate hematopoiesis following chemotherapy. Apart from stimulating production of granulocytes and monocytes/macrophages, GM-CSF has also long been used for in vitro survival/generation of dendritic cells (DCs) from monocytes and bone marrow cells. Evidence has emerged pointing to an additional role for GM-CSF in regulating the function and differential development of several DC subsets. These newly ascribed functions of GM-CSF may underscore its importance in immunity against pathogens as well as initiating/mediating immunopathology in chronic inflammation. Here we summarize recent advances on the role of GM-CSF in regulating the development and function of DC subsets and discuss the biological significance of these new findings. (C) 2012 Elsevier Ltd. All rights reserved.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- COLONY-STIMULATING FACTOR; MYCOBACTERIUM-TUBERCULOSIS INFECTION; ANTIGEN-PRESENTING FUNCTIONS; COLLAGEN-INDUCED ARTHRITIS; LEUKEMIA INHIBITORY FACTOR; MOUSE LYMPHOID ORGANS; CD4 T-CELLS; IN-VIVO; CROSS-PRESENTATION; LANGERHANS CELLS
- Research Division(s)
- Immunology
- Publisher's Version
- https://doi.org/10.1016/j.molimm.2012.04.009
- Terms of Use/Rights Notice
- Copyright © 2012 Elsevier Ltd. All rights reserved.
Creation Date: 2012-08-01 12:00:00