Development of antigen cross-presentation capacity in dendritic cells
- Author(s)
- Dresch, C; Leverrier, Y; Marvel, J; Shortman, K;
- Details
- Publication Year 2012-08,Volume 33,Issue #8,Page 381-388
- Journal Title
- TRENDS IN IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Cross-presentation by dendritic cells (DCs) of exogenous antigens on MHC class I is important for the generation of immune responses to intracellular pathogens, as well as for maintenance of self tolerance. In mice, the CD8(+) DC lineage is specialised for this role. However, DCs of this lineage are not born with cross-presentation capacity. Several studies have demonstrated that it must be induced as a later developmental step by cytokines such as granulocyte macrophage colony-stimulating factor (GM-CSF), or by microbial products such as toll-like receptor (TLR) ligands. Increased cross-presentation capacity is thus induced in peripheral CD8 lineage DCs during inflammation or infection. However, this capacity is already fully developed in steady-state thymic CD8(+) DCs, in accordance with their role in the deletion of self-reactive developing T cells.
- Publisher
- ELSEVIER SCI LTD
- Keywords
- TOLL-LIKE RECEPTORS; STEADY-STATE; BONE-MARROW; T-CELLS; CENTRAL TOLERANCE; LYMPHOID ORGANS; SPLENIC CD8(+); IN-VIVO; GM-CSF; PRECURSORS
- Research Division(s)
- Immunology
- Publisher's Version
- https://doi.org/10.1016/j.it.2012.04.009
- Terms of Use/Rights Notice
- Copyright © 2012 Elsevier Ltd. All rights reserved.
Creation Date: 2012-08-01 12:00:00