Hematopoietic stem cells, progenitor cells and leukemic stem cells in adult myeloproliferative neoplasms
- Author(s)
- Ng, AP;
- Details
- Publication Year 2013-05,Volume 54,Issue #5,Page 922-933
- Journal Title
- LEUKEMIA & LYMPHOMA
- Publication Type
- Journal Article
- Abstract
- The understanding of myeloproliferative neoplasms has changed dramatically since Dameshek proposed his classification over 50 years ago. Our knowledge of the types of cells which constitute the hematopoietic system and of how they are regulated has also appreciated significantly over this time. This review relates what is currently known about the acquired genetic mutations associated with adult myeloproliferative neoplasms to how they lead to the hematopoietic perturbations of myeloproliferative disease. There is a particular focus on how stem and progenitor cell compartments are affected by BCR-ABL1 and JAK2V617F mutations, and the particular issue of resistance of leukemic stem cells to conventional and targeted therapies.
- Publisher
- INFORMA HEALTHCARE
- Keywords
- CHRONIC MYELOID-LEUKEMIA; CHRONIC MYELOGENOUS LEUKEMIA; TYROSINE KINASE INHIBITORS; COLONY-STIMULATING FACTOR; COMPLETE MOLECULAR REMISSION; PLUS INTERFERON-ALPHA; EARLY CHRONIC PHASE; RENEWAL IN-VIVO; POLYCYTHEMIA-VERA; BCR-ABL
- Research Division(s)
- Cancer And Haematology
- Publisher's Version
- https://doi.org/10.3109/10428194.2012.734615
- Terms of Use/Rights Notice
- Copyright © 2012 Informa Plc. All rights reserved.
Creation Date: 2013-05-01 12:00:00