Modulating T regulatory cells in cancer: how close are we?
- Author(s)
- Banerjee, A; Vasanthakumar, A; Grigoriadis, G;
- Details
- Publication Year 2013-05,Volume 91,Issue #5,Page 340-349
- Journal Title
- IMMUNOLOGY AND CELL BIOLOGY
- Publication Type
- Journal Article
- Abstract
- Regulatory T cells (Tregs) are a specialized subset of CD4 T cells that have an indispensable role in maintaining immune homeostasis and tolerance. Although studies in mice and humans have clearly highlighted that the absence of these cells results in severe autoimmunity and inflammation, increased Treg numbers and/or function is not always beneficial. This is best exemplified in certain cancers where increased Tregs promote cancer progression by interfering with immune surveillance. Conversely, in other types of cancers that have an inflammatory component, Tregs can inhibit cancer progression by dampening inflammation. In this review article, we provide a historical perspective of the discovery of Tregs, followed by a summary of the existing literature on the role of Tregs in malignancy.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- TRANSCRIPTION FACTOR FOXP3; LYMPHOCYTE-ASSOCIATED ANTIGEN-4; ACUTE MYELOID-LEUKEMIA; MAJOR HISTOCOMPATIBILITY COMPLEX; TUMOR-INFILTRATING LYMPHOCYTES; ACUTE MYELOGENOUS LEUKEMIA; ARYL-HYDROCARBON RECEPTOR; X-LINKED SYNDROME; INDOLEAMINE 2,3-DIOXYGENASE; DENDRITIC CELLS
- Research Division(s)
- Molecular Immunology
- Publisher's Version
- https://doi.org/10.1038/icb.2013.12
- Terms of Use/Rights Notice
- © 2013 Australasian Society for Immunology
Creation Date: 2013-05-01 12:00:00