CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse

Author(s): Wiede, F; Fromm, PD; Comerford, I; Kara, E; Bannan, J; Schuh, W; Ranasinghe, C; Tarlinton, D; Winkler, T; McColl, SR; Korner, H;
Details: Publication Year 2013-05,Volume 91,Issue #5,Page 335-339
Journal Title: IMMUNOLOGY AND CELL BIOLOGY
Publication Type: Journal Article
Abstract: The CC-chemokine receptor 6 (CCR6) is expressed constitutively at an intermediate level on naive B cells and is upregulated after activation on pregerminal center (GC) B cells. We hypothesized that it could be involved in the events leading to GC reaction and high-affinity antibody production, and therefore investigated the potential role of CCR6 in B-cell differentiation in vivo. After antigenic challenge of CCR6(-/-) mice with the T-cell-dependent antigen nitrophenyl-keyhole limpet hemocyanin (NP-KLH), GC B-cell development was found to be accelerated and the number of GC had increased significantly compared with control mice, but the antibodies produced by CCR6(-/-) B cells were on average of lower affinity. We conclude from these data that the CCR6/CCL20 axis has an important role in regulating the kinetics and efficiency of the GC reaction.
Publisher: NATURE PUBLISHING GROUP
Research Division(s): Immunology
Publisher's Version: https://doi.org/10.1038/icb.2013.14

Creation Date: 2013-05-01 12:00:00